Negative alactic base excess is reversed by hemoperfusion in septic patients

Introduction: Gattinoni et al. have recently introduced a new parameter: the “alactic base excess” (ABE). ABE is equivalent to number of strong acids, other than lactate, which are present in plasma abnormal concentrations, negative being associated with higher mortality sepsis. Hemoperfusion (HPF) an extracorporeal procedure that involves passage blood through adsorption cartridge, where solutes removed by direct binding sorbent material. Then, it was decided explore influence HPF on value Materials and methods: Basal values ABE, standard excess (SBE), lactate (mean, deviation [SD]) were obtained. The difference between these parameter before after four sessions (HA330) (delta value) evaluated. Student’s t-test Wilcoxon test applied. Results: From 32 patients (age: 57±13) suffering from respiratory insufficiency secondary COVID-19 who treated critical care unit Clinica de la Mujer, Bogotá (Colombia), 6 presented metabolic acidosis (‒2.7±1) SBE (‒4.7±1) high serum (2±0.7 mmol/L). Delta SBE, were: 7.7 (p = 0.005), 6.1 0.003), 1.6 NS), respectively. Thus, significantly reversed HPF, since turned positive without significant change lactate. Conclusion: Negative alactic septic patients. It necessary carry out evaluations larger groups estimate their impact clinical outcomes.